The RZ67 is a modular camera system, meaning the lenses, viewfinders, ground glass, film winders and film backs designed for the system are all interchangeable. The RZ67's Sekor lenses have built-in electronic leaf shutters which are cocked and triggered from the body. Focusing is performed with a set of bellows.

The camera accepts 120 and 220 film film with film backs configurable for 6×7 cm, 6×6 cm and 6×4.5 cm exposures. These backs are rotating, allowing for both landscape and portrait orientation without removing the back. Special-purpose backs allow for the use of Polaroid film as well as Quadra 72 4×5 sheet film. Mamiya RB67 backs are also supported via the G-Adapter. The film speed is set on each RZ back via a dial. There are two versions of the 6×7 and 6×4.5 backs. The model II versions have a second film counter to always show the film count on the top, regardless of the back orientation.

The RZ67 operates on one 6V 4SR44 silver oxide battery, or 6V 4LR44 alkaline battery. It can be used in an emergency with a mechanical mode fixed at 1/400 sec shutter speed. Multiple exposures are possible in the M-mode. Mirror lock up is supported for long exposures and macro photography. The body has one standard flash hot shoe on its left side, one plug for a standard shutter cable release, and a PC socket for an electronic shutter trigger. The RZ67 measures 104mm (W) × 133.5mm (H) × 211.5mm (L) with the 110mm f/2.8 lens, and weighs approximately 2.4 kg (5.29 lbs). The flange distance is 105mm.